Coronavirus | What is dexamethasone and how it works

Dexamethasone anti-inflammatory steroid tablets
The knowledge that the anti-inflammatory drug dexamethasone can significantly help in the treatment of Kovid-19 patients with a severe clinical picture is considered a great discovery in research aimed at effectively fighting the coronavirus. British research has shown that this steroid could save lives - the first such drug - and that it can be used immediately in treatment.

Coronavirus: Anatomy of a pandemic Coronavirus: This is not the last pandemic What kind of medicine is that? Dexamethasone is a steroid - a drug that reduces inflammation by mimicking the hormones that the body secretes in that fight. How does it work?

Coronavirus infection creates inflammation, so the body tries to fight it. But the immune system is sometimes overloaded and such a reaction can often be fatal. The reaction that is supposed to attack the infection starts to attack the cells that only the body produces. Dexamethasone calms this effect. However, this medicine can only be used for patients who are in the hospital and are connected to oxygen or respirators - patients with a severe clinical picture. The drug does not work on people with milder symptoms, because suppressing the immune system in that condition would not be helpful.



How effective is it?


According to the scientists who conducted the research, one in three deaths can be prevented among patients on respirators. For those connected to oxygen, it can prevent one in five deaths. There is no significant effect on patients who do not have difficulty breathing.


When was the research done?


The results are the conclusion of the Recovery study (Randomized Evaluation of Covid-19 therapy -), conducted by the University of Oxford. It was tested whether existing drugs used in the treatment of other diseases could be helpful against Kovid-19. About 2,100 patients received a dose of six milligrams of dexamethasone over a 10-day period. Everything about the coronavirus - in small doses A life-saving drug - a big step forward in the fight against coronavirus

Their progress was compared with a random sample of 4,300 patients who did not receive therapy. Scientists hope that dexamethasone could be used as part of a therapy that, in combination with other drugs, would further reduce mortality. It is now recommended for adults, but not for pregnant women or mothers.


How much medicine is available?


Dexamethasone is a cheap drug that already exists and is available in sufficient quantities. It was first made in 1957, and its widespread use began in 1960. Because it has been on the market for so long, the drug is not patented, which means that several different companies can produce it. This is especially good news for developing countries and the World Health Organization has praised the results of the research,


What other ailments is it used for?


The drug helps in the treatment of various diseases that accompany inflammation or swelling of the body or those conditions in which the immune system is overloaded. For example, it is used in severe forms of asthma that can cause inflammation of the airways or lungs and severe allergic reactions. Dexamethasone is also useful in autoimmune diseases such as rheumatoid arthritis or lupus when the immune system mistakenly attacks the body.


Are there any side effects?



Common side effects in the treatment of other diseases are anxiety, difficulty sleeping, weight gain, and inability to urinate. There are rare cases of changes in the eyes, blurred vision, and bleeding. However, Kovid-19 patients were given only a small dose that should reduce side effects. A study in England showed that there were no side effects among patients receiving dexamethasone therapy.
Coronavirus | What is dexamethasone and how it works Coronavirus | What is dexamethasone and how it works Reviewed by Hamza Ali on June 21, 2020 Rating: 5

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